FGFR3 alterations are a prevalent potential driver in oncology, with continuous activation of the FGFR signalling pathway driving multiple tumourigenic processes across tumour types.[1][2][3][4]As altered FGFR signalling is common in a wide variety of cancers, FGFR alterations represent an important potential target for treatment.[3]
FGFR3 alterations are most commonly found in UC and have been identified across all grades and/or stages of bladder cancer[3][5]
All in all, the molecular biomarkers and pathways involved in UC are key to understanding its biological heterogeneity and identifying specific subtypes, which may be used to predict treatment outcomes.[6] Therefore, a focus on the distinct molecular subtypes in UC could help you see your individual LA/mUC patients more clearly.[7]
Discuss available biomarkers and related molecular testing options with your pathologist today to better understand your patients’ tumour growth drivers[8][9]
▼ Este medicamento está sujeito a monitorização adicional. Titular da Autorização de Introdução no Mercado: Janssen-Cilag International NV, Turnhoutseweg 30, B-2340 Beerse, Bélgica.
Para mais informações deverá contactar o Representante do Titular da Autorização de Introdução no Mercado: Janssen-Cilag Farmacêutica, Lda.
Medicamento de receita médica restrita, de utilização reservada a certos meios especializados.
RCM de Balversa®, veja aqui.
FGFR: fibroblast growth factor receptor; LA: locally advanced; mUC: metastatic UC; UC: urothelial carcinoma.